GnRH signaling pathway
| PAG Title | GnRH signaling pathway |
| PAG ID | WAG000603 |
| Type | P |
| Source Link |  KEGG |
| Publication Reference | NA |
| PAG Description | Godotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the godotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its sigl to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kise C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasiolly observed in a cell-specific fashion. Sigling downstream of protein kise C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kises (MAPKs), including extracellular-sigl-regulated kise (ERK), Jun N-termil kise (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 2,622 |
| Information Content | Rich |
| Other IDs | hsa04912 |
| Base PAG ID | WAG000603 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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